The organization of the repeats was unusual. They accidentally cloned part of a CRISPR sequence together with the " iap" gene (isozyme conversion of alkaline phosphatase) from the genome of Escherichia coli which was their target. The first description of what would later be called CRISPR is from Osaka University researcher Yoshizumi Ishino and his colleagues in 1987. The discovery of clustered DNA repeats took place independently in three parts of the world. In 2022, in a proceeding at the United States Patent and Trademark Office (interference 106,115), the Patent Trial and Appeal Board decided that the inventor for the US patent covering application of CRISPR-Cas9 in eukaryotic cells is Feng Zhang, a professor of the Broad Institute. The development of the CRISPR-Cas9 genome editing technique was recognized by the Nobel Prize in Chemistry in 2020 which was awarded to Emmanuelle Charpentier and Jennifer Doudna. This editing process has a wide variety of applications including basic biological research, development of biotechnological products, and treatment of diseases. Cas9 enzymes together with CRISPR sequences form the basis of a technology known as CRISPR-Cas9 that can be used to edit genes within organisms. This comes in handy if you have loud fans and want to minimize the amount of noise they make, or if you just need to save some battery life.Diagram of the CRISPR prokaryotic antiviral defense mechanism Ĭas9 (or "CRISPR-associated protein 9") is an enzyme that uses CRISPR sequences as a guide to recognize and cleave specific strands of DNA that are complementary to the CRISPR sequence. On the other hand, you can set it to the “High Performance” preset to allow your computer to run at full potential. For example, you can set your CPU to the “Quiet” preset, which tells your computer to only use a maximum of 30% of its resources. Its simple drop-down menu allows the user to change between various preset or user-made profiles that control at what frequency your CPU is to run. CPU Power Management allows you to choose how much of your computer’s resources are being used at any given time. This is an extension that, at first, I didn’t think would be very useful, but after some time using it I have found that functionality like this should be backed into all computers by default. But, if you want a bit more control, this extension can help both Intel and Ryzen-based machines. The ability to toggle between performance modes is now available with recent Linux distributions and newer Linux Kernel releases. This makes things convenient, considering all your important applications get organized right after you sign in your system. It is as simple as adding an application to the list and selecting the desktop you would like that application to open on.įrom then on, every time you open that application, it will open on that particular workspace. Auto-Move Windows allows you to set your applications to automatically open on a workspace/virtual desktop of your choice. If you utilize multiple virtual desktops (or workspaces) like me, this extension will make your workflow much easier. The list is in no particular order of ranking, meaning the extension listed at one is not better than the rest. So, the list of the best GNOME extensions should save you some time. But finding good extensions can be a daunting task. ![]() We already have a resource for you to enable and manage GNOME extensions. These extensions add a lot of value to the ecosystem, whether it is to mold the GNOME Desktop Environment (DE) to your workflow, to add more functionality than there is by default, or simply to freshen up the experience. ![]() GNOME extensions are a major part of the GNOME experience.
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